Are there any protocol or host software changes required when dropping in a PRM240-R2 to replace an LT1110/PRM240 module?

Answer

No. The PRM240-R2 utilizes the same robust Server-Client FHSS wireless protocol (up to 230 kbps RF data rate). It supports the standard UART interface and configures seamlessly via Ezurio’s Configuration and Test Utility Software, as explained in the Configuration and Test Utility Software  User Guide- RAMP Modules