Answer
There is an registry key - "ComDB". You can find it in - HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\COM Name Arbiter. 1) Right click that key, and select "Modify". 2) In value Data section select all and delete reset to Zero ?0?. Once you restart the computer, all coms are free.You will need to reinstall on all com port devices. It is always good to do back up of the registry before deleting any entry from registry, and we are not liable to any damage to your computer.